Baker's yeast mediated mono-reduction of 1,3-cyclohexanediones bearing two identical C(2) substituents

Autor:	Zu-Yi Li, Guo-Qiang Lin, Zhi-Liang Wei
Rok vydání:	2001
Předmět:	Inorganic Chemistry Steric effects Biotransformation Stereochemistry Chemistry Organic Chemistry Physical and Theoretical Chemistry Enantiomer Catalysis Yeast
Zdroj:	Tetrahedron: Asymmetry. 12:229-233
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(01)00015-5
Popis:	Baker's yeast mediated transformation of a series of 1,3-cyclohexanediones with two identical substituents at C(2) was investigated and the results of the biotransformation were found to depend on the size of the substituents at C(2). 1,3-Cyclohexanediones with less sterically demanding C(2) substituents could be mono-reduced to provide the corresponding ketols in good yields and excellent enantiomeric excesses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b63bd3b98c610c383c3204f57046570 https://doi.org/10.1016/s0957-4166(01)00015-5 Zobrazit plný text záznamu Full Text from ScienceDirect