Facile syntheses of aryldifluorophosphonate building blocks

Autor:	Howard J. Easterfield, Jonathan M. Percy, G. Stuart Cockerill
Rok vydání:	1999
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Aryl Organic Chemistry Drug Discovery Biochemistry Trifluoromethanesulfonate Phosphonate Stille reaction
Zdroj:	Tetrahedron Letters. 40:2601-2604
ISSN:	0040-4039
Popis:	The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F 2 Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-Miyaura couplings. Herein, we report a streamlined synthesis of F 2 Pmp, and of a pivotal triflate, which undergoes a range of palladium-catalysed couplings with aryl and heteroaryl components.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b5a73ff9795a4d3e966c51dd14bcb24 https://doi.org/10.1016/s0040-4039(99)00266-x Zobrazit plný text záznamu Full Text from ScienceDirect