Self‐Assembled Structures of Catanionic Associations: How to Optimize Vesicle Formation?

Autor:	Cécile Bize, Isabelle Rico-Lattes, Muriel Blanzat
Rok vydání:	2010
Předmět:	chemistry.chemical_classification General Chemical Engineering Carboxylic acid Bilayer Vesicle Micelle Surfaces Coatings and Films Self assembled chemistry Pulmonary surfactant Amphiphile Drug delivery Polymer chemistry Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Journal of Surfactants and Detergents. 13:465-473
ISSN:	1558-9293 1097-3958
Popis:	Like other amphiphilic compounds, bolaforms do not always possess surfactant properties; it depends on the spacer chain length and the nature of the polar head group (both sufficiently hydrophobic or hydrophilic, respectively, to intensify the amphiphilic properties). In this regard, unsymmetrical bolaamphiphiles bearing a sugar polar head group and a carboxylic acid function at the opposite ends of a hydrophobic binding spacer were synthesized. These biocompatible sugar-derived bolaforms were associated with basic fatty amines, by an acid–base reaction, to obtain catanionic mixtures. Associations with 1,7-lactobionamidoheptanoic acid and decylamine or octylamine spontaneously form stable 200–600 nm vesicles. This new type of association may find an application in drug delivery since catanionic vesicles can transport active substances inside the hydrophilic core, as well as hydrophobic drugs within the bilayer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b5054a723c17f6c64bd3d5864b9f485 https://doi.org/10.1007/s11743-010-1181-z Zobrazit plný text záznamu Full text from SpringerLink Plný text