Absorption Enhancing Effect of Sodium Dodecyl Sulfate on Metformin Hydrochloride in Rat Colon

Autor:	Guo Feng Li, Ruo Yu Liu, Hua Fan, Longquan Shao, Yu Liu, Dong Dong Jing
Rok vydání:	2013
Předmět:	Chromatography Chemistry Mechanical Engineering Inorganic chemistry Ileum Absorption (skin) Metformin Hydrochloride chemistry.chemical_compound medicine.anatomical_structure Mechanics of Materials In vivo medicine General Materials Science Sodium dodecyl sulfate Absorption rate constant
Zdroj:	Key Engineering Materials. 544:426-430
ISSN:	1662-9795
DOI:	10.4028/www.scientific.net/kem.544.426
Popis:	The aim of this study was to observe the absorption enhancing effect of sodium dodecyl sulfate on metformin hydrochloride in colon of rat. Using in vivo intestinal loop model in rat while the ileum was took as blank group and colon as the experiment groups with different concentration of sodium dodecyl sulfate (1%, 2%, 4%). The colon/ileum ratio of the absorption rate constant of metformin hydrochloride was evaluated through calculating the residual dose of circulating solution in presupposition time points. Intergroup absorption rate constant and the rising percent of the absorption rate constant were different significantly (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b3fedf16fa3b984440b069839cd4968 https://doi.org/10.4028/www.scientific.net/kem.544.426 Zobrazit plný text záznamu