Clinical evaluation of a pasteurized factor XIII concentrate administration in Henoch-Schönlein purpura
| Autor: | T. Nagao, K. Yoshioka, J. Akatsuka, S. Shike, Kaneo Yamada, Shunichi Miyazaki, Y. Kobayashi, Hidekazu Kamitsuji, M. Nakashima, Akira Shirahata, S. Tanaka, Hiroshi Fukui, S. Maki, Minoru Inagaki |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Henoch-Schonlein purpura business.industry Coagulation factor XIII Hematology medicine.disease Factor XIII Gastroenterology Clinical trial Purpura Internal medicine Blood plasma Immunology medicine Abdominal symptoms medicine.symptom business Clinical evaluation medicine.drug |
| Zdroj: | Thrombosis Research. 56:667-675 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(89)90284-3 |
| Popis: | Arthral, abdominal and renal symptoms in Henoch-Schonlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level was correlated with the severity score of clinical symptoms, particularly abdominal symptoms. Based on the results, a controlled study was performed in 24 cases with moderate symptoms divided into a group treated with F XIII concentrate and a non-treated group to investigate clear-cut efficacy as a next study. In three days after the administration the symptoms were improved remarkably in accordance with the increase of F XIII level compared with non-treated group and scoring of clinical symptoms was confirmed to be useful for assessing the application of the F XIII concentrate to HSP. |
| Databáze: | OpenAIRE |
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