Effects of Gonadal Steroids and Electrical Stimulation on Cell Survival following Intracranial Facial Nerve Injury

Autor:	Muhamad Amine, Gina N. Monaco, Brent J. Benscoter, Eileen M. Foecking, Sam J. Marzo, Ryan C. Burgette
Rok vydání:	2013
Předmět:	Testosterone propionate business.industry Right facial nerve Sham surgery Stimulation medicine.disease Facial nerve Facial nerve injury chemistry.chemical_compound Otorhinolaryngology chemistry Anesthesia Crush injury medicine Surgery business Cell survival
Zdroj:	Otolaryngology–Head and Neck Surgery. 149
ISSN:	1097-6817 0194-5998
Popis:	Objectives:The purpose of this study was to assess 1) the degree of motoneuron cell loss and 2) the combinatorial effects of electrical stimulation (ES) and testosterone propionate (TP) on cell survival following an intracranial facial nerve crush injury and 3) to compare these results to distal injuries.Methods:Study Design: Prospective, randomized, controlled animal study. Sprague-Dawley rats were randomly divided into three groups: intracranial sham surgery or intracranial crush injury with or without ES and TP treatments. The intracranial sham group underwent exposure of the meatal segment of the right facial nerve. The intracranial crush groups underwent a crush of the meatal segment following exposure with or without ES and TP treatment immediately following the injury and were followed for 8 weeks. Brain sections were thionin-stained, and facial motoneurons were counted using light microscopy. Results were compared to intratemporal and extracranial facial nerve crush injuries.Results:Intracranial c...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b3c66e2b6f4f189cb77bee8378d4f72 https://doi.org/10.1177/0194599813495815a191 Zobrazit plný text záznamu Plný text