The meliacins (limonoids): minor constituents of Khaya anthotheca: reduction of the meliacins with zinc–copper couple
Autor: | D.E.U. Ekong, Joseph I. Okogun, B. Lucas Sondengam |
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Rok vydání: | 1975 |
Předmět: | |
Zdroj: | J. Chem. Soc., Perkin Trans. 1. :2118-2122 |
ISSN: | 1364-5463 0300-922X |
DOI: | 10.1039/p19750002118 |
Popis: | The residues collected after isolation of anthothecol from Khaya anthotheca have afforded a new meliacin for which the structure (2b)(11β-acetoxyazadirone) is proposed. In addition, deacetylanthothecol and a sterol mixture shown by g.l.c. to consist of stigmasterol, β-sitosterol, campesterol, cycloeucalenol, and 24-methylenecycloartanol, were isolated. In the course of model experiments with anthothecol aimed at structural correlation with the new compound, zinc–copper couple was found to be a convenient and superior reagent for reduction of epoxides to olefins, αβ-unsaturated ketones to saturated ketones, and ketols and their acetates to ketones, in the meliacin series. By using this reagent new reduction products of anthothecol have been prepared and characterised. |
Databáze: | OpenAIRE |
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