Long-term outcome in chronic inflammatory demyelinating polyneuropathy patients treated with intravenous immunoglobulin: A retrospective study
| Autor: | José Luis Muñoz-Blanco, Rafael Sivera, Luis Querol, Eduardo Gutiérrez-Rivas, Carmen Paradas, María J. Sedano, José L. Capablo, Carlos Casasnovas, Julio Pardo, Ricard Rojas-García, Isabel Illa, Maria Antonia Alberti, A. Guerrero, Teresa Sevilla |
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| Rok vydání: | 2013 |
| Předmět: |
Immunoglobulin A
medicine.medical_specialty Response to therapy biology Physiology business.industry Chronic inflammatory demyelinating polyneuropathy Retrospective cohort study medicine.disease Response to treatment Surgery Term (time) Cellular and Molecular Neuroscience Physiology (medical) Internal medicine biology.protein Medicine In patient Neurology (clinical) Demyelinating polyneuropathy business |
| Zdroj: | Muscle & Nerve. 48:870-876 |
| ISSN: | 0148-639X |
| Popis: | Neurology Department, Hospital Universitario “12 de Octubre”, Madrid, SpainAccepted 11 March 2013ABSTRACT: Introduction: The objective of this retrospectivestudy was to describe the short- and long-term patterns of IVIguse, safety, and response to treatment in patients with chronicinflammatory demyelinating polyneuropathy (CIDP). Methods:Response to therapy was defined as an improvement of 1point on the modified Rankin score at short- and mid-term vis-its. Patient status at long term was classified as remission, sta-bility, or non-responder. Results: Eighty-six patients wereincluded; 60.5% responded at short term and 54.6% at mid-term. At long term, 25.6% of patients were in remission, 65.1%were stable, and 9.3% were non-responders. The only variableassociated with remission was a better response during the first6 months of follow-up. Conclusions: A significant percentage ofpatients did not require any additional drugs in the long term.This suggests that treatment effect or disease outcome may bestable over time, and treatment regimens should therefore beindividualized to avoid overtreatment. |
| Databáze: | OpenAIRE |
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