Pharmacological characterization of FE 201874, the first selective high affinity rat V1Avasopressin receptor agonist

Autor:	Gilles Guillon, Julie Mion, Evelyne Galibert, Zahia Meraihi, Dominique Haddou, Anne Virsolvy, Michel G. Desarménien, Rafik Marir, Kazimierz Wisniewski
Rok vydání:	2013
Předmět:	Pharmacology Arginine vasopressin receptor 1B Agonist 0303 health sciences medicine.drug_class HEK 293 cells Biology Partial agonist 03 medical and health sciences 0302 clinical medicine Biochemistry Arginine vasopressin receptor 2 medicine Inverse agonist Receptor 030217 neurology & neurosurgery 030304 developmental biology Vasopressin receptor
Zdroj:	British Journal of Pharmacology. 170:278-292
ISSN:	0007-1188
DOI:	10.1111/bph.12249
Popis:	BACKGROUND AND PURPOSE Distinct vasopressin receptors are involved in different physiological and behavioural functions. Presently, no selective agonist is available to specifically elucidate the functional roles of the V1A receptor in the rat, one of the most widely used animal models. FE 201874 is a new derivative of the human selective V1A receptor agonist F180. In this study, we performed a multi-approach pharmacological and functional characterization of FE 201874 to determine whether it is selective for V1A receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b32e527f71eb0598419bdf4a4f04625 https://doi.org/10.1111/bph.12249 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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