An anomalous intramolecular conjugate addition of N-protected imidazoles to vinyliminophosphoranes promoted by tetrabutylammonium fluoride. X-Ray crystal structure of 5-ethoxycarbonyl-5-(triphenylphosphoranylidene-amino)-5,6-dihydroimidazo[2,1-α]isoquinoline

Autor:	A. Lorenzo, Concepción Foces-Foces, Enrique Aller, Pedro Molina, Antonio Luis Llamas Saiz
Rok vydání:	1996
Předmět:	Hydrogen Hydrogen bond Organic Chemistry chemistry.chemical_element Crystal structure Biochemistry Crystal chemistry.chemical_compound Crystallography chemistry Intramolecular force Drug Discovery Molecule Isoquinoline Conjugate
Zdroj:	Tetrahedron. 52:13671-13680
ISSN:	0040-4020
DOI:	10.1016/0040-4020(96)00819-8
Popis:	An anomalous intramolecular conjugate addition of N-SEM protected imidazoles to vinyliminophosphoranes proceeds efficiently in the presence of tetrabutylammonium fluoride (TBAF) to afford the corresponding fused imidazoles. The crystal and molecular structure of 4 have been solved by X-Ray analysis. The crystal packing is governed by weak C-H…X (X=O, N or aromatic π system) hydrogen interactions because the absence of more polarized donor groups to form hydrogen bonds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b2c3c34b169930ada52b7fb4fc44fcd https://doi.org/10.1016/0040-4020(96)00819-8 Zobrazit plný text záznamu Full Text from ScienceDirect