Drug-Induced Injury of the Gastrointestinal System and Methods for Its Correction (A Review)
| Autor: | O. I. Stepanova, E. L. Matveyenko, N. N. Karkischenko, R. A. Klesov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty Gastrointestinal tract 030109 nutrition & dietetics medicine.drug_class business.industry Stomach media_common.quotation_subject Antibiotics 030209 endocrinology & metabolism General Medicine Gastrointestinal system 03 medical and health sciences 0302 clinical medicine Immune system medicine.anatomical_structure Pharmacotherapy medicine Stem cell Intensive care medicine business media_common |
| Zdroj: | Journal Biomed. 16:14-34 |
| ISSN: | 2074-5982 |
| Popis: | Common complications of pharmacotherapy involve damage to the gastrointestinal tract, development of resistance to traditional therapy, destruction of the intramural nervous system of the intestines, changes in the opportunistic microflora, dysfunctions of the intestinal immune system. According to WHO experts, diseases of the digestive system are expected to become one of the leading causes of disability. This paper reviews current publications on drug-induced injuries of the gastrointestinal tract, including those induced by drugs aimed at preventing such conditions. Side effects of NSAIDs, glucocorticoids, minerals, neuroleptics, antibiotics, cytostatics, saluretics, anticoagulants, contraceptives, as well as enemas, suppositories and other drugs are described. Published review papers paid significant attention to drug-induced injuries of the stomach; however, there is a lack of data on drug-induced lesions of the gastrointestinal tract. This paper aims to brigde this gap. New approaches to correction and organ protection are described. The epigenetic issues related to the pluripotency of stem cells are considered. In the Russian Federation, a regulatory framework was created to regulate all the fundamental processes associated with the production and use of biomedical cell products and biotechnologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|