Cerebral Toxoplasmosis in a Treatment Naive HIV Patient with High CD4 Count Responding to Treatment with a Regime of Cotrimoxazole and Pyrimethamine: Do We Need to Start Prophylaxis for Toxoplasmosis at a Higher CD4 Count?

Autor:	Abhijit Swami, Riturag Thakuria, Sumit Kharat
Rok vydání:	2015
Předmět:	medicine.medical_specialty Pediatrics Opportunistic infection business.industry Human immunodeficiency virus (HIV) medicine.disease medicine.disease_cause Toxoplasmosis Surgery Serology Therapy naive Cerebral toxoplasmosis Pyrimethamine medicine Hiv patients business medicine.drug
Zdroj:	HIV/AIDS Research and Treatment - Open Journal. 2:72-75
ISSN:	2377-8377
Popis:	Cerebral toxoplasmosis is one of the commonest opportunistic infection of the nervous system in HIV patients. We present a case of gradual onset haemiparesis in an ART naive HIV patient with high CD4 count who was subsequently diagnosed to be a case of cerebral toxoplasmosis based on radiological and serological investigations. The patient responded to a regime of Cotrimoxazole and Pyrimethamine. His CD4 count at diagnosis was 299/μl. HAART was started after completion of treatment of cerebral toxoplasmosis. Prophylaxis against toxoplasmosis is recommended with cotrimoxazole if the CD4 count is below 200/μl. However, in this case as the patient had developed toxoplasmosis at a CD4 count value above the cut-off value for prophylaxis for cerebral toxoplasmosis, it may be worth considering to starting prophylaxis at a higher CD4 count than 200/μl and continuing for a longer time than the current guidelines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b177531e276e71fe726fe0f5ef63f96 https://doi.org/10.17140/hartoj-2-111 Zobrazit plný text záznamu