| Autor: |
A. R. Ruiz-Fernández, Boris E. Weiss-López, Sebastian E. Gutierrez-Maldonado, Tomas Perez-Acle, Felipe Villanelo, Claudia Pareja-Barrueto |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
RSC Advances. 10:15366-15374 |
| ISSN: |
2046-2069 |
| Popis: |
Lyotropic liquid crystals (LLCs) are mixtures of amphiphile molecules usually studied as mimetic of biological membrane. The equilibrium dynamics of tetradecyltrimethyl ammonium cation (TTA+) molecules forming nematic LLCs (LNLCs) is guided by a dive-in mechanism where TTA+ molecules spontaneously leave and re-enter the bicelle. Of note, this dynamic behavior could be exploited to produce drug nano-delivery systems based on LNLCs. Therefore, the understanding of the effect of pharmaceutically interesting molecules in the dynamics of the dive-in mechanism should be crucial for drug delivery applications. In this work, we studied the effects of L-DOPA in the equilibrium dynamics of TTA+ bicelles forming LNLCs, employing a transdisciplinary approach based on 2H-NMR together with molecular modeling and molecular dynamics simulations. Our data suggest that L-DOPA perturbs the kinetic of the dive-in mechanism but not the thermodynamics of this process. As whole, our results provide fundamental insights on the mechanisms by which L-DOPA govern the equilibrium of LNLCs bicelles. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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