4 Risks associated with antidepressants in patients with hypertension during pregnancy: a retrospective cohort study
| Autor: | Peter Ter Horst, Marlieke Oude Weernink, Elvera Damer, Mireille Edens, Marieke Hemels |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Archives of Disease in Childhood. 108:A1.4-A1 |
| ISSN: | 1468-2044 0003-9888 |
| Popis: | IntroductionGiven the proportion of pregnant women with gestational hypertension or pre-eclampsia using an antidepressant we aimed to gain insight into the effects concerning for both mother and neonate especially on birth weight, APGAR score, and pregnancy duration.Study designRetrospective cohort study of women with hypertension disorders, whether or not using antidepressants.Main outcome measures: Birth weight, APGAR score, admittance to Obstetrical High Care unit (OHC) and or Neonatal Intensive Care Unit and pregnancy durationResultsThe use of antidepressants was associated with lower APGAR scores at 10 minutes, p= 0.008, OR = 2.298; 95% CI 1.255–4.273, compared to neonates from mothers without antidepressants. Women using antidepressants were more often admitted to the OHC (crude OR= 1.95; p=0.049; 95% CI 0.99–3.77). Multivariable logistic regression analysis revealed that thyroid disease and preterm ending of pregnancy contributed to the model, where use of antidepressants remained significant (OR=6.28; 95% CI 2.32–18.31).ConclusionsWomen with hypertension disorders during pregnancy and using antidepressants might have an increased risk for complications leading to OHC admission. |
| Databáze: | OpenAIRE |
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