Clinical Evaluation of Mometasone Furoate Nasal Spray(1st Report). Dose Comparison Study in Japanese Cedar Pollenosis

Autor:	Teruhisa Noiri, Satoshi Ogino, Morihiro Irifune, Hiroe Goto, Osamu Senba
Rok vydání:	1999
Předmět:	business.industry medicine.medical_treatment Dose comparison Pollenosis Low dose Mometasone furoate Otorhinolaryngology Nasal spray Anesthesia medicine Clinical efficacy business Clinical evaluation medicine.drug
Zdroj:	Practica Oto-Rhino-Laryngologica. 92:309-324
ISSN:	1884-4545 0032-6313
DOI:	10.5631/jibirin.92.309
Popis:	The clinical efficacy and safety of 200 μg/day (100μg b. i. d) of mometasone furoate nasal spray (MFNS) administered for 2 weeks was evaluated by comparison with a low dose of MFNS of 50μg/day (50μg o. d.) using the envelope-method in a total of 65 patients with Japanese cedarpollenosis.The pollen counts for Japanese cedar in 1995 were extremely high in the Kansai district. About 5, 000 counts/cmz was confirmed in and around Osaka.In the analysis of final overall improvement, marked or moderate improvement was observed in 76.2% (16/21) and 20.8% (5/24) of patients receiving MFNS 200μg/day and 50μg/day, respectively. The difference in efficacy between the two dosage groups was confirmed independently of timing of the initiation of administration. In the analysis of overall safety, high safety was observed with both treatments. The above results suggest that 200μg/day of MFNS can be considered the recommended dose for the treatment of Japanese cedar pollenosis.
Databáze:	OpenAIRE
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