Nitric Oxide Generation from Aromatic N-Nitrosoureas at Ambient Temperature

Autor:	Masayuki Tanno, Naoki Miyata, Shoko Sueyoshi, Shigeo Nakagawa
Rok vydání:	1996
Předmět:	Chloroform Inorganic chemistry Snap General Chemistry General Medicine Photo irradiation Nitric oxide No donors chemistry.chemical_compound chemistry Griess test Drug Discovery Tetraphenylporphyrin Krebs buffer
Zdroj:	Chemical and Pharmaceutical Bulletin. 44:1849-1852
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.44.1849
Popis:	Generation of nitric oxide (NO) from aromatic N-nitrosoureas 1-3 at ambient temperature without photo irradiation was confirmed by the trapping of NO as a nitrosyl complex of 5, 10, 15, 20-tetrahenylporphyrinatocobalt(II) and spectrophotometrically quantified by means of the Griess reaction using a newly designed test apparatus in which NO-2 is generated from NO. 3, 3-Dibenzyl-1-(4-tolyl)-1-nitrosourea (1a) showed the greatest NO-generation ability among compounds 1-3 and N-acetyl-S-nitroso-DL-penicillamine (SNAP) in chloroform. A comparison of 1a and usual NO donors (NOC-18, NOR-4, SIN-1, SNAP, and SNP) in Krebs buffer was also made using the same test apparatus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b102fb1f8e17ab72edd43f0bc60ed63 https://doi.org/10.1248/cpb.44.1849 Zobrazit plný text záznamu