Role of Helicobacter pylori in the triggering and evolution of hemorrhagic gastro‑duodenal lesions
| Autor: | Cecil Sorin Mirea, Vlad Dumitru Baleanu, Mihai Silviu Tudosie, Bogdan Niculescu, Marian Diaconescu, Laura Tribus, Meda Comandasu, Dragoş George Popa, Cosmin Vasile Obleaga, Dragos Serban, Bogdan Socea, Dan Nicolae Florescu, Cristian Meșină, Ionică Daniel Vîlcea, Marius Eugen Ciurea |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty biology business.industry Cancer General Medicine Helicobacter pylori biology.organism_classification medicine.disease Gastroenterology Immunology and Microbiology (miscellaneous) Gastro Internal medicine Hemostasis medicine In patient Upper gastrointestinal bleeding business Complication Gastroenterology clinic |
| Zdroj: | Experimental and Therapeutic Medicine. 22 |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The majority of studies concerning Helicobacter pylori (H. pylori) are oriented towards the implication of infection with H. pylori in processes that end in the formation of neoplasia, without assessing the impact of the bacterium in triggering acute gastroduodenal hemorrhagic episodes. The present study includes 166 patients with upper digestive hemorrhage, admitted to the ATI Clinic, the Gastroenterology Clinic or to the Surgery II Clinic of the County Emergency Clinical Hospital in Craiova, Romania between 2017 and 2019. All patients were monitored for evolution and received treatment according to current guidelines, and hemorrhagic lesions were biopsied. In the study group, 56.8% of the patients with upper gastrointestinal bleeding (UGIB) were positive for H. pylori and 43.2% were negative. In patients less than 50 years of age, non-steroidal anti-inflammatory drug (NSAID) use and H. pylori infection had a cumulative effect in causing bleeding lesions, but in patients older than 50 years of age, the use of NSAIDs was replaced by therapies with oral antiplatelet or anticoagulant agents. The need for hemostasis surgery was more common in patients who exhibited H. pylori-positive UGIB compared to H. pylori-negative (16 vs. 9.7%). In patients with H. pylori-positive hemorrhagic lesions, gastric resection was frequently required to obtain hemostasis. Persistence of H. pylori infection in patients with a history of gastric resection (4.1%) still predisposes to a hemorrhagic or neoplastic complication. |
| Databáze: | OpenAIRE |
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