Incomplete functional and morphological recovery after acute and acute recurrent pancreatitis in children
| Autor: | Subhamoy Das, Rajendra Prasad, Narendra Dhaka, Sadhna B Lal, S.V. Rana, Kishore Kamal, Rama Walia, Rajini Thakur, Srikanth Puttaiah Kadyada, Babu Ram Thapa, Karanvir Kaushal |
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| Rok vydání: | 2018 |
| Předmět: |
Endoscopic ultrasound
medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Gastroenterology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Insulin resistance Interquartile range Median follow-up 030220 oncology & carcinogenesis Internal medicine medicine Acute pancreatitis Pancreatitis 030211 gastroenterology & hepatology Prediabetes Pancreas business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 34:293-301 |
| ISSN: | 0815-9319 |
| Popis: | BACKGROUND AND AIM There is lack of data on functional and morphological recovery after an attack of acute pancreatitis (AP) or acute recurrent pancreatitis (ARP) in children. This study aims to evaluate the functional impairment and morphological changes in the pancreas after recovery. METHODS All consecutive patients presenting with AP (n = 61) or ARP (n = 35), as per standard diagnostic criteria, were enrolled. After 2 months of pancreatitis, fecal elastase-1 (FE-1) (μg/g) and 2-h oral glucose tolerance test to calculate oral disposition index (DIo ) (mmol/L) (β-cell function) were performed. Morphological changes were assessed by endoscopic ultrasound and transabdominal ultrasound. Patients with chronic pancreatitis (CP) (n = 27) and healthy children (HC) (n = 26) were included as controls for functional parameters. RESULTS At a median follow up of 12 (4-44) and 11 (2-108) months, 66.7% and 75.9% (P = 0.57) of AP and ARP demonstrated exocrine insufficiency (FE-1 |
| Databáze: | OpenAIRE |
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