ChemInform Abstract: Diastereocontrolled Reduction of Cyclic β-Enaminones. A New Diastereoselective Route to 2,6-Disubstituted Piperidines

Autor:	Philippe Delbecq, Gérard Lhommet, Vu Moc Thuy, H. Petit, J. P. Celerier, Stéphanie Fréville
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Reduction (complexity) Ketone chemistry Organic chemistry General Medicine
Zdroj:	ChemInform. 32
ISSN:	0931-7597
DOI:	10.1002/chin.200140217
Popis:	A new diastereoselective synthesis of 2,6-disubstituted piperidinic alkaloids is presented. Three natural compounds, the (−)-pinidinone 1a , the (+)-dihydropinidine 1b and the (−)-pinidinol 1c were prepared from optically pure (6 R )-6-methylpiperidin-2-one 2 . This method is based on the chemo- and diastereocontrolled reductions of an exocyclic β-enamino ketone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b0bc7c72e7e46974b5c794e9b6cffe9 https://doi.org/10.1002/chin.200140217 Zobrazit plný text záznamu Plný text