Evaluating mild cachexia syndrome in the HIV-positive pregnant woman
| Autor: | Amanda L. Wilkinson, Todd Jim, Michael Denna, Joann M. McDermid, Urassa Mark, Changalucha John, Sarah H. Pedersen, Safari Kinung’hi, Andreasen Aura |
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| Rok vydání: | 2019 |
| Předmět: |
Pregnancy
030219 obstetrics & reproductive medicine business.industry Human immunodeficiency virus (HIV) Inflammation General Medicine medicine.disease medicine.disease_cause Cachexia 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Immunology medicine medicine.symptom business Immune activation |
| Zdroj: | African Journal of Midwifery and Women's Health. 13:1-13 |
| ISSN: | 2052-4293 1759-7374 |
| Popis: | Background Immune activation and inflammation are common symptoms throughout HIV infection and lead to elevated circulating concentrations of cachectic cytokines. Aims To evaluate cachexia-like symptoms among HIV-positive and HIV-negative pregnant women, and investigate whether cachexic mechanisms may contribute to impaired HIV-exposed fetal and infant growth. Methods Pregnant women (n=114; 39% HIV-positive) were prospectively enrolled from an antenatal clinic in semi-rural Tanzania. Maternal cachexia-associated plasma cytokines and hormones, and clinical and anthropometric data were assessed. Cachexia scores were quantified using a novel adaptation of a validated cachexia scoring system. Infant growth anthropometry was measured at birth and after 6 months. Results Maternal cachexia score was inversely associated with infant birth weight, birth length, and weight-for-age z-score at 6 months. Conclusions Symptoms consistent with a mild cachectic state were associated with poorer infant outcomes. This effect was greater for HIV-exposed infants. A better understanding of the maternal cachexia burden and implications for maternal and infant health in HIV, other infections, and inflammatory conditions is needed. |
| Databáze: | OpenAIRE |
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