Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression
| Autor: | Kazuhiro Kogawa, Daisuke Kobayashi, Akiko Sada, Toshio Tanaka, Shigeaki Nonoyama, Kohsuke Imai |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment B-Cell Lymphoblastic Leukemia medicine.disease Myeloid antigen Leukemia hemic and lymphatic diseases Pediatrics Perinatology and Child Health Immunology medicine Eosinophilia medicine.symptom business Interleukin 5 Biomedical sciences Interleukin 3 |
| Zdroj: | Pediatrics International. 54:543-546 |
| ISSN: | 1328-8067 |
| Popis: | Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES. |
| Databáze: | OpenAIRE |
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