| Popis: |
Acinetobacter baumannii has become a challenging conditional pathogen. A. baumannii can lead to different infections, such as wound or urinary tract infections and pneumonia. As an alternative strategy for antibiotic-resistant A. baumannii infections, phage therapy had been used and approved by several governments. Previously we had reported two potential phage therapy candidates named Abp1 and Abp9. In this study, a wide host range lytic phage Abp95 were isolated and sequenced. The biological characteristics of Abp95 are also stuied. Abp95 belongs to the myoviridae family, containing a G+C content of 38.07% with a genome of 43,176 bp. Abp95 genome encodes 77 hypothetical genes, without any known virulence genes. With a diabetic wound infection model, Abp95 could accelerate wound healing though clearing local infections of multidrug-resistant A. baumannii. In conclusion, wide host range lytic phage Abp95 shows the potential as phage therapy candidate against multi-genotypes of Carbapenem-Resistant Acinetobacter baumannii. |
