Histamine H2 Receptors in Nasal Mucosa
| Autor: | Kohtaro Baba, Shigehiko Satoh, Hitoshi Shimada |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
business.industry Type i allergy Mucous membrane Mucous membrane of nose Histamine H1 receptor Nasal allergy chemistry.chemical_compound medicine.anatomical_structure Endocrinology Otorhinolaryngology Histamine H2 receptor chemistry Internal medicine Immunology medicine business Histamine |
| Zdroj: | Practica Oto-Rhino-Laryngologica. 87:1281-1286 |
| ISSN: | 1884-4545 0032-6313 |
| DOI: | 10.5631/jibirin.87.1281 |
| Popis: | Nasal mucous membrane is a pathogenic site of Type I allergy (nasal allergy), and a number of studies have suggested the involvement of histamine H1 receptors in this region.Histamine H2 receptors, which are considered to suppress the activity of many immunity-related cells have, however been studied insufficiently.In this study, the number of histamine H2 receptors was compared in 15 patients with allergic rhinitis and 19 non-allergic patients who had been treated with naso-sinus resection.Their inferior nasal conchal mucosa specimens showed the following:Bmax(maximum bound volume) was 52.95± 15.09 fmol/mg-protein in the allergic group, significantly higher than the 25.5 ± 3.72 fmol/mg-protein volue in the non-allergic group.In the allergic group, Bmax in those below 40 years of age was 61.61 ± 18.07 fmol/mg protein, significantly higher than the 18.20 ± 5.44 fmol/mg-protein value in those over 40 years of age. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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