EFFECTS OF A TYPICAL ANTIPSYCHOTIC AND THROMBOXANE A2 SYNTHASE INHIBITOR DRUG COMBINATION ON ALBUMIN AND TOTAL PROTEIN LEVEL WITH DIFFERENT DOSES IN RATS

Autor:	Muhammad Irfan Bashir
Rok vydání:	2019
Předmět:	Pharmacology Drug ATP synthase biology medicine.drug_class media_common.quotation_subject Albumin Pharmaceutical Science Typical antipsychotic Thromboxane A2 chemistry.chemical_compound chemistry biology.protein medicine Pharmacology (medical) Total protein media_common
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :316-319
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2019.v12i7.34122
Popis:	Objective: The objective of this study was to investigate the combined as well as individual effects of a typical antipsychotic and thromboxane A2 synthase inhibitor on albumin and total protein level with minimum and maximum dose comparison in rats. Methods: This study consisted of 100 albino rats of 300 to 340 g from both gender, there were 10 groups, each contained 10 rats (n=10). Rats were treated with defined dose of zuclopenthixol (Zuclo) and ozagrel (Ozg) for 21 days (3 weeks). Blood samples were collected at 0, 7th, 14th, and 21st days of study. Albumin and total protein level were examined from blood samples using standard laboratory procedure. Results are extracted by applying statistical analysis on data and comparing percentage variation from 0-day value. Results: A typical antipsychotic-treated group showed gradually significant increase in albumin and total protein level, TXA2 synthase inhibitor-treated group also showed significant gradually increase in albumin and total protein level in combination groups, they showed highly significant increase p
Databáze:	OpenAIRE
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