Myoglobin-Latextest: Ein neuer Schnelltest zur Verbesserung der Frühdiagnostik des akuten Myokardinfarktes
| Autor: | B. Strobel, H E Keller, B Kleinschnittger, K. Paschen, M. G. Bachem |
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| Rok vydání: | 2008 |
| Předmět: |
Every Two Hours
medicine.medical_specialty business.industry Radioimmunoassay General Medicine medicine.disease Latex fixation test chemistry.chemical_compound Myoglobin chemistry Shock (circulatory) Internal medicine medicine Cardiology Latex test Myocardial infarction diagnosis Myocardial infarction medicine.symptom business |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 108:1190-1194 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1069720 |
| Popis: | Myoglobin concentrations were determined radioimmunologically and with a semiquantitative rapid latex test in 684 serum samples. There was a good correlation of both tests. The latex test becomes positive above 90 micrograms/l, i.e. the diagnostically relevant range. Myoglobin was determined in 27 patients with acute myocardial infarction at the same time as serum values of enzymes CK, CK-MB, LDH and GOT. This was done during three days every two hours. Diagnostically useful myoglobin increases were found on average already 2.6 +/- 0.9 hours after onset of pain, i.e. 3-4 hours before the first increase of enzymes CK-MB and CK. Out of 85 patients with acute myocardial infarction already 70% had a positive myoglobin latex test at the time of admission. In contrast, only 30% had increased enzyme activities (CK and CK-MB). Non-infarct-associated increases of myoglobin in serum were seen in patients with terminal renal failure, severe shock, muscle trauma, muscle diseases, alcohol intoxication and after reanimation. |
| Databáze: | OpenAIRE |
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