| Popis: |
To design self-assembly nanocarrier to maintain a particular biological function is the main goal of bionanobiology. Biodegradable and biocompatible materials are more preferred to prevent the polymer remaining in the body, in the preparation of particles for drug delivery purpose. An advantage of particles that are produced based on proteins is that, not only they are safe in biological purposes, but also they contain functional -COOH and -NH2 groups, the effective cross linking agents. It is important to make the couple nano ring system more stable with a nanoplymer with biocompatibility, low cost, high performance and lightweight such as poly(lactic acid). The heterocyclic nanorings were designed with three constant members of glycine and three variable amino acid members. The effect of Poly-L-lactate chain was introduced as the main biodegradable, and easy to produce and use nano support. All systems were analyzed physicochemically by computational methods. Temperature as the mail surrounding r effect is considered in this investigation. Geometrical changes in order to increase temperature may cause the rings near each others, to form a new geometrical optimization and attract each other more. The results considered that, different utilization for various drugs structure, with any type of hydrophobicity or hydrophilicity, any dipole moment, suitable couple rings based on the obtained results, could be designed. Poly electrolytes such as polylactic acid (PLA) make the systems more strong, to deliver a pack of drugs, for example in production of arterial stents. Key words: Hetero cyclic hexa peptide nanoring, polylactic acid, drug delivery, biocompatible, biodegradable, quantum mechanics. |
