A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma
| Autor: | Andrey A. Yarovoy, Jason C. S. Yam, Tero Kivelä, Brenda L. Gallie, Jonathan W. Kim, Ekaterina Semenova, Guillermo Chantada, Genoveva Correa-Llano, Adriana Fandiño, Matthew W. Wilson, Suganeswari Ganesan, Ashwin Mallipatna, Jaume Català, Sonia Moorthy, Elisa Carreras, Olga V Yugay, Ankit Singh Tomar, Junyang Zhao, Marco A. Ramirez-Ortiz, Tatiana L Ushakova, Michala Burges, Vikas Khetan, Vera Adobea Essuman, Chengyue Zhang, Winnie W. Y. Lau, V.G. Polyakov, Yacoub A. Yousef, Paula Schaiquevich, Kalle Nummi, Carol P. S. Lam, Phillipa Sharwood, Rachel C. Brenna, Paul T. Finger, Elena Kotova, Quah Boon Long, Vera Yarovaya, Lorna Renner, Elizabeth Esparza-Aguiar |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Chemotherapy medicine.medical_specialty genetic structures Retinoblastoma business.industry medicine.medical_treatment Enucleation Cancer medicine.disease Intraocular Retinoblastoma eye diseases Treatment failure 3. Good health Surgery 03 medical and health sciences Ophthalmology 0302 clinical medicine Treatment success 030221 ophthalmology & optometry medicine sense organs business 030304 developmental biology Cancer staging |
| Zdroj: | Ophthalmology. 127:1733-1746 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/j.ophtha.2020.05.051 |
| Popis: | Purpose To evaluate the ability of the American Joint Committee on Cancer (AJCC) 8th edition to predict local tumor control and globe salvage for children with retinoblastoma (RB). Design International, multicenter, registry-based retrospective case series. Participants A total of 2854 eyes of 2097 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents. Methods International, multicenter, registry-based data were pooled from patients enrolled between January 2001 and December 2013. All RB eyes with adequate records to allow tumor staging by the AJCC 8th edition criteria and follow-up to ascertain treatment outcomes were included. Main Outcome Measures Globe-salvage rates were estimated by AJCC clinical (cTNMH) categories and tumor laterality. Local treatment failure was defined as use of enucleation or external beam radiation therapy (EBRT), with or without plaque brachytherapy or intra-arterial chemotherapy (IAC). Results Unilateral RB occurred in 1340 eyes (47%). Among the 2854 eyes, tumor categories were cT1 to cT4 in 696 eyes (24%), 1334 eyes (47%), 802 eyes (28%), and 22 eyes (1%), respectively. Of these, 1275 eyes (45%) were salvaged, and 1179 eyes (41%) and 400 eyes (14%) underwent primary and secondary enucleation, respectively. The 2- and 5-year Kaplan–Meier cumulative globe-salvage rates without the use of EBRT by cTNMH categories were 97% and 96% for category cT1a tumors, 94% and 88% for cT1b tumors, 68% and 60% for cT2a tumors, 66% and 57% for cT2b tumors, and 32% and 25% for cT3 tumors, respectively. Risk of local treatment failure increased with increasing cT category (P Conclusions Multicenter, international, internet-based data sharing validated the 8th edition AJCC RB staging to predict globe-salvage in a large, heterogeneous, real-world patient population with RB. |
| Databáze: | OpenAIRE |
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