Pretibial myxoedema: stilmulation of mucopolysaccharide production of fibroblasts by serum

Autor:	D.S. Jolliffe, P.M. Gaylarde, I. Sarkany, A.P. Brock
Rok vydání:	1979
Předmět:	medicine.medical_specialty business.industry Thyroid disease Stimulation Human skin Dermatology medicine.disease Somatomedin In vitro medicine.anatomical_structure Endocrinology Internal medicine Medicine business Fibroblast
Zdroj:	British Journal of Dermatology. 101:557-560
ISSN:	1365-2133 0007-0963
Popis:	SUMMARY We have shown that sera from normal individuals and from patients with pretibial myxoedema contain a factor which stimulates mucopolysaccharide biosynthesis in normal human skin fibroblasts cultured in vitro. This factor was present in larger amounts in sera of patients with pretibial myxoedema. The role of growth stimulating factors in serum is reveiwed and a hypothesis is put forward that the fibroblast stimulating factor is somatomedin and that its presence in increased amounts in thyroid disease may lead to pretibial myxoedema.
Databáze:	OpenAIRE
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