Synthesis and psychotropic activity of 5-cyclohexyl-5-methyl-2-sulfanyl-3,4,5,6-tetrahydrobenzo[h]quinazolin-4-one

Autor:	R. G. Paronikyan, N. P. Grigoryan, R. S. Sukasyan, A. I. Markosyan, L. A. Tarzyan
Rok vydání:	2011
Předmět:	Pharmacology chemistry.chemical_compound Ethylene chemistry Sulfanyl Quinazolin-4-one Drug Discovery Pharmacology toxicology Triazole Organic chemistry Tetrazole Grignard reagent
Zdroj:	Pharmaceutical Chemistry Journal. 45:79-83
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-011-0564-4
Popis:	Ethyl 2-cyano-3-cyclohexyl-3-methyl-4-phenylbutanoate was synthesized from ethyl (2Z)-2-cyano-3cyclohexylbut-2-enoate using a Grignard reagent. It was shown that the reaction occurred exclusively at the ethylene bond. Because this cyanoester contained two asymmetric centers, PMR spectra showed two diastereoisomeric forms. These were cyclized in the presence of conc. H2SO4 into ethyl 4-amino-2-cyclohexyl-2-methyl-1,2-dihydronaphthalenecarboxylate, which was used to synthesize benzo[h]quinazolines, alkyl-substituted benzo[h]quinazolines, triazole, and tetrazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7aeea144a77c84bfd4d1065abd7aafcd https://doi.org/10.1007/s11094-011-0564-4 Zobrazit plný text záznamu Plný text ve formátu PDF