Maternal sex hormones in early pregnancy and asthma among offspring

Autor:	Baizhuang Xu, Tuula Husman, Juha Pekkanen, Leea Keski-Nisula, Pentti Koskela
Rok vydání:	2003
Předmět:	medicine.medical_specialty Pregnancy Allergy biology business.industry Offspring Immunology medicine.disease Atopy Endocrinology Sex hormone-binding globulin Internal medicine medicine biology.protein Immunology and Allergy Gestation business Asthma Hormone
Zdroj:	Journal of Allergy and Clinical Immunology. 112:1101-1104
ISSN:	0091-6749
DOI:	10.1016/j.jaci.2003.09.027
Popis:	Background Sex hormones may be associated with the risk of onset of asthma. Objective To study the association between maternal sex hormone concentrations during early pregnancy and the risk of asthma among offspring. Methods A case-control study of 129 asthmatic children and 125 control children 5 to 6 years of age. Maternal sera in early pregnancy were obtained from the Finnish Maternal Cohort serum bank. Results The means of serum progesterone and estradiol and free estradiol in mothers of asthmatic and control children were 81.0 and 82.8 nmol/L ( P = .60), 7.87 nmol/L and 7.65 nmol/L ( P = .99), and 149.5 pmol/L and 148.0 pmol/L ( P = .95), respectively. There were also no differences in the mean concentrations of maternal sex hormones according to the presence of allergic rhinitis or atopic eczema among the children. Conclusions The current results do not support an association between maternal sex hormone concentrations during early pregnancy and onset of allergic disease in early childhood.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7aece5387242b5e2f1a94f10f5aa110d https://doi.org/10.1016/j.jaci.2003.09.027 Zobrazit plný text záznamu Full Text from ScienceDirect