ChemInform Abstract: Synthesis and Mechanistic Studies of a ′Tetrazole-Tethered′ Cephalosporin-Quinolone Hybrid

Autor:	S. L. Dax, Rossman Pamela Loreen, David L. Pruess, Wei Chung-Chen
Rok vydání:	2010
Předmět:	Hydrolysis chemistry.chemical_compound medicine.drug_class Chemistry Cephalosporin Antibiotics medicine Tetrazole General Medicine Antibacterial activity Quinolone Combinatorial chemistry In vitro
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199332273
Popis:	The synthesis and antibacterial activity of a novel ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The in vitro spectrum of 7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lactamase-accelerated hydrolysis of 7 produced tetrazolylquinolone 12 which (via independent synthesis) proved to be a weak antibacterial and unable to form free quinolone.
Databáze:	OpenAIRE
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