Arrivacins, novel pseudoguaianolide esters with potent angiotensin II binding activity from Ambrosia psilostachya

Autor:	Mark F. Bean, Barbara N. Timmermann, Cecily Chambers, Terry A. Francis, Priscilla Offen, Michael J. Huddleston, John Westley, Brad Carte, Yongle Chen
Rok vydání:	1991
Předmět:	Angiotensin receptor biology Chemistry Stereochemistry Dimer Organic Chemistry Sesquiterpene biology.organism_classification Biochemistry Chloride Angiotensin II chemistry.chemical_compound Membrane Drug Discovery medicine Methylene Ambrosia psilostachya medicine.drug
Zdroj:	Tetrahedron. 47:4869-4878
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)80953-4
Popis:	Two novel pseudoguaianolide esters, arrivacins A ( 1 ) and B ( 2 ), have been isolated from the methylene chloride extract of Ambrosia psilostachya collected in Arrivaca Cienega, Arizona. The structures of the arrivacins, which are examples of sesquiterpene dimers formed from the condensation of two different pseudoguaianolide sesquiterpenes, were determined by analysis of the spectral data and chemical interconversion. Arrivacins A and B show potent binding to angiotensin II receptors in bovine adrenal membranes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ae7d3971a26990f452e1a99f9c9d7cd https://doi.org/10.1016/s0040-4020(01)80953-4 Zobrazit plný text záznamu