Separation of Taxol and Cephalomannine by Countercurrent Chromatography

Autor:	I-Ming Chu, Chau-Jen Lee, Pei Kan, Fu-Ying Chiou
Rok vydání:	1997
Předmět:	Solvent system Chromatography Ethanol Resolution (mass spectrometry) Chemistry Clinical Biochemistry Ethyl acetate Pharmaceutical Science Cephalomannine Biochemistry Analytical Chemistry Hexane chemistry.chemical_compound Countercurrent chromatography Organic chemistry Methanol
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 20:57-61
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826079708010636
Popis:	Countercurrent chromatography was used to separate taxol from cephalomannine, on a preparative scale for the final purification of taxol. A solvent system consisting of hexane:ethyl acetate:methanol: ethanol:water in 5:7:5:1:6.5 was found to be suitable in achieving near base-line resolution of the two components. It was found that the amount of methanol in the solvent system was very critical to a successful separation operation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7adfd8bd603f770744a02e4c73217ad9 https://doi.org/10.1080/10826079708010636 Zobrazit plný text záznamu