Ethanol extract of Tephrosia bracteolata leaves and its fractions ameliorates alloxan-induced diabetes and its associated complications in Wistar rat model

Autor: Daniel Emmanuel Ekpo, Precious Adejoh Idakwoji, Okwesilieze Fred Chiletugo Nwodo, Obioma U. Njoku, Parker Elijah Joshua
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Diabetes in Developing Countries. 41:456-468
ISSN: 1998-3832
0973-3930
DOI: 10.1007/s13410-020-00900-w
Popis: Tephrosia bracteolata Guill. & Perr. (Leguminosae-Papilionoideae) is a traditional Nigerian medicinal plant used for the treatment of whitlow, toothache, wounds, and diabetes. This study investigated the biochemical and histopathological effects of the ethanol extract of T. bracteolata leaves (EETB) and its fractions on alloxan-induced diabetic rats. EETB was fractionated successively with n-hexane, chloroform, ethyl acetate, methanol, and water to yield the respective fractions (nHF, CF, EAF, MF, and AF). The antidiabetic activities of EETB and its fractions at 250 and 500 mg/kg body weight (groups 4–15) were investigated in comparison to the normal control (group 1), the diabetic control (group 2), and the standard (150 mg/kg b.w. metformin, group 3) on alloxan-induced diabetic Wistar rats (200–220 g) for 28 days. Alterations in some biochemical parameters and histopathology of major organs were assessed. Induction of diabetes triggered significant (p
Databáze: OpenAIRE
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