A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl
| Autor: | Alberdan Silva Santos, Daniella P. A. Grisólia, Moises Batista da Silva, Milton N. da Silva, Alberto C. Arruda, Ronilson Freitas de Souza, Geilson Alcantara da Silva, Mara S.P. Arruda, Claudio Guedes Salgado |
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| Rok vydání: | 2016 |
| Předmět: |
Antifungal
Chromatography biology 010405 organic chemistry Stereochemistry medicine.drug_class General Chemistry Fabaceae Isoflavones Vatairea guianensis biology.organism_classification 01 natural sciences Corpus albicans 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry medicine Two-dimensional nuclear magnetic resonance spectroscopy Candida dubliniensis Lupiwighteone |
| Zdroj: | Journal of the Brazilian Chemical Society. |
| ISSN: | 0103-5053 |
| DOI: | 10.21577/0103-5053.20160250 |
| Popis: | A new compound, 5,7,3’-trihydroxy-4’-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4’-trihydroxy-3’-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1 H and 13 C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3’-trihydroxy4’-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis. |
| Databáze: | OpenAIRE |
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