HPV-Associated Oropharyngeal Cancer in the HIV/AIDS Patient
| Autor: | Michael E. Hagensee, Jennifer E. Cameron |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cervical cancer Oncology medicine.medical_specialty Oral hairy leukoplakia business.industry virus diseases Cancer Context (language use) medicine.disease medicine.disease_cause female genital diseases and pregnancy complications stomatognathic diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) 030220 oncology & carcinogenesis Internal medicine Epidemiology Carcinoma medicine Carcinogenesis business |
| Zdroj: | Cancer Treatment and Research ISBN: 9783030035013 |
| DOI: | 10.1007/978-3-030-03502-0_6 |
| Popis: | Since their discovery as the etiologic agents of cervical cancer in the mid-1970s, human papillomaviruses (HPVs) have been linked with a growing number of epithelial-derived tumors, including head and neck squamous cell carcinomas. HPV demonstrates a particular predilection for causing tumors of the oropharynx, with the majority of cases involving infection with high-oncogenic risk HPV-16. People living with HIV are at increased risk of infection with HPV- and HPV-related oral complications even with adequate control of their HIV infection with antiretroviral therapy. In this chapter, we discuss the molecular mechanisms that underlie HPV-mediated oncogenesis in the oropharynx. We also describe the progress that has been made in understanding the epidemiology of oral HPV infection and the determinants of oral HPV-related pathology. Finally, we examine what can be done to treat and prevent oral HPV infection, benign lesions, and cancer, particularly in the context of the HIV-positive patient. |
| Databáze: | OpenAIRE |
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