Phenolic compounds and in vitro antioxidant, anti-inflammatory, antimicrobial activities of Scorzonera hieraciifolia Hayek roots
| Autor: | Aynur Sari, B. Özbek Çelik, Nurten Ozsoy, Hasan Şahin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Antioxidant biology medicine.medical_treatment Ethyl acetate Plant Science Quinic acid Antimicrobial biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Chlorogenic acid chemistry medicine Caffeic acid Petroleum ether Food science Scorzonera 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 125:116-119 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2019.07.009 |
| Popis: | Scorzonera L. (Asteraceae) species are widespread and utilised as traditional medicine and edible plant. A phytochemical study on ethyl acetate fraction obtained from the ethanol extract of Scorzonera hieraciifolia Hayek (an endemic species of Turkey) roots resulted in isolation of nine compounds; 5-O-feruloyl quinic acid methyl ester (1), 1,5-di-O-feruloylquinic acid (2), chlorogenic acid methyl ester (3), 3-O-caffeoylquinic acid methyl ester (4), 1,3-di-O-caffeoylquinic acid methyl ester (5), 3,5-di-O-caffeoylquinic acid methyl ester (6), 4,5-di-O-caffeoylquinic acid methyl ester (7), caffeic acid (8), 3-(4’-Hydroxyphenyl)-2-propenoic acid (4″-carboxyl)-phenyl ester (9). Structures of the compounds were determined using spectral methods. All substances were isolated for the first time from this species and compound 9 is new for the family Asteraceae. In vitro antioxidant, anti-inflammatory and antimicrobial activities of petroleum ether, chloroform, ethyl acetate and n-butanol fractions were evaluated. Ethyl acetate fraction showed the highest amount of total phenolic content and antioxidant capacity. No significant antimicrobial activity was determined against tested bacteria and fungi. COX inhibition test was employed for anti-inflammatory studies, all fractions showed low inhibitory effect on both COX-1 and COX-2 enzymes in comparison with indomethacin. |
| Databáze: | OpenAIRE |
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