Communication—Cucurbituril Mediated Electronic Identification of Single Nucleobases

Autor:	Bohuai Xiao, Yunchuan Li, Shuai Chang
Rok vydání:	2022
Předmět:	Renewable Energy Sustainability and the Environment Materials Chemistry Electrochemistry Condensed Matter Physics Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Journal of The Electrochemical Society. 169:057523
ISSN:	1945-7111 0013-4651
DOI:	10.1149/1945-7111/ac700a
Popis:	Electronically detecting and identifying four DNA nucleosides offers great opportunity in DNA sequencing. By introducing a cage-shaped molecule cucurbit[7]uril (CB[7]) into the tunneling junction to capture nucleobases, we show that all four DNA nucleobases can be better detected and identified, in contrast to the results measured with bare electrodes, and a conductivity order of T < A ∼ C < G can be clearly revealed with a correct single base read up to 84% from each individual tunneling signal. This work provides a unique electronic approach in identifying single DNA bases and paves the way for the realization of high-precision DNA single-molecule analysis using tunneling current.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ac87897963317d399768a16de4c805a https://doi.org/10.1149/1945-7111/ac700a Zobrazit plný text záznamu