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Hyperglycemia is the fundamental cause of diabetes complications. The major consequence of hyperglycemia is the increased accumulation of advanced glycation end products (AGEs). AGE formation is initiated by nonenzymatic reactions between carbonyl groups of reducing sugars and free amino groups. These AGEs bring about an alteration in the structure of macromolecules, especially proteins by causing aggregation and crosslinking. The invention of novel antiglycation and antiaggregation compounds from different sources has received great attention. Several natural compounds and their active constituents have the property of reducing adverse effects of aggregation and glycation of proteins. Being an acceptable historical and culture-based treatment for various health issues, Nigella sativa is a phytomedicine that has been gaining worldwide recognition. Traditionally and recent research papers suggest its therapeutic significance for the treatment of various ailments like diabetes, cancer, liver diseases, etc. It is rich in many phytochemicals and medicinally important compound. The following book chapter deals with the role of N. sativa (black cumin) seeds and its active constituents in the prevention of glycation and glycation-induced aggregation and oxidation of macromolecules. |
