Immobilized tetrakis(triphenylphosphine)palladium(0) for Suzuki–Miyaura coupling reactions under flow conditions
| Autor: | Jenny-Lee Panayides, G. Valerie Ramaotsoa, Darren L. Riley, Ian Strydom |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Fluid Flow and Transfer Processes
Single pass 010405 organic chemistry Process Chemistry and Technology chemistry.chemical_element Tetrakis(triphenylphosphine)palladium(0) 010402 general chemistry 01 natural sciences Catalysis Coupling reaction 0104 chemical sciences chemistry.chemical_compound Flow conditions chemistry Chemistry (miscellaneous) Polymer chemistry Precipitation polymerization Chemical Engineering (miscellaneous) Triphenylphosphine Palladium |
| Zdroj: | Reaction Chemistry & Engineering. 4:372-382 |
| ISSN: | 2058-9883 |
| DOI: | 10.1039/c8re00235e |
| Popis: | An immobilized triphenylphosphine scaffold was prepared by precipitation polymerization and functionalized to afford a cost-effective source of solid-supported tetrakis(triphenylphosphine)palladium(0). The catalyst was characterised and used to perform biphasic Suzuki–Miyaura cross-coupling reactions using a packed-bed reactor under flow conditions. The approach afforded comparable yields to those obtained under batch conditions with a single pass through the packed-bed reactor (1 h vs. 18 h). The use of a recycling system was investigated on a model reaction and found to afford close to quantitative conversion within 3 hours. |
| Databáze: | OpenAIRE |
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