Uric Acid as Prognostic Marker in Advanced Nonischemic Dilated Cardiomyopathy: Comparison With N-Terminal Pro B-Type Natriuretic Peptide Level
| Autor: | Kwon-Bae Kim, Yun-Kyeong Cho, Chang-Wook Nam, Choon-Duk Han, Hyoung-Seob Park, Hyuck-Jun Yoon, Yoon-Nyun Kim, Jihyun Son, Seung Ho Hur, Hong-Won Shin, Hyungseop Kim |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry medicine.drug_class Cardiomyopathy Area under the curve Renal function Hemodynamics Emergency Nursing medicine.disease chemistry.chemical_compound chemistry Internal medicine Heart failure Emergency Medicine Natriuretic peptide Cardiology Medicine Uric acid cardiovascular diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | Congestive Heart Failure. 16:153-158 |
| ISSN: | 1751-7133 1527-5299 |
| DOI: | 10.1111/j.1751-7133.2010.00144.x |
| Popis: | Although uric acid (UA) level has been associated with an increased risk of cardiovascular events, it is unclear whether UA can provide greater prognostic information than N-terminal pro B-type natriuretic peptide (NT-proBNP) in advanced heart failure with nonischemic dilated cardiomyopathy (DCM). UA and NT-proBNP values were obtained from a total of 122 DCM patients. Development of clinical events during follow-up was defined as the composite of cardiac death and readmission for heart failure. During follow-up, there were 18 cardiac events. UA and NT-proBNP values were significantly higher in patients with events. The receiver operating characteristics curve showed the area under the curve for UA was greater than that for NT-proBNP. On multivariate analysis, UA remained the only independent predictor of prognosis. UA concentrations > or =8.7 mg/dL rather than NT-proBNP > or =3800 pg/mL were associated with significantly decreased event-free survival. The authors' findings demonstrated that UA value could be an informative predictor in nonischemic DCM. |
| Databáze: | OpenAIRE |
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