Comparative anti-inflammatory properties of Capsaicin and ethylaAcetate extract of Capsicum frutescens linn [Solanaceae] in rats
| Autor: | J A O Ojewole, A T Jolayemi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
biology Side effect business.industry medicine.drug_class Analgesic Ethyl acetate General Medicine Pharmacology biology.organism_classification Anti-inflammatory law.invention Surgery chemistry.chemical_compound Diclofenac chemistry law Capsaicin Medicine business Phytotherapy Solanaceae medicine.drug |
| Zdroj: | African Health Sciences. 13 |
| ISSN: | 1680-6905 |
| DOI: | 10.4314/ahs.v13i2.23 |
| Popis: | Background : The analgesic effect of capsaicin (the active ingredient in Capsicum frutescens Linn. [Solanaceae]) had been reported in several studies. Current research is being directed at producing analgesics, anti-inflammatory agents with better side effect profile. Objectives : To investigate if either the ethyl acetate extract of Capsicum frutescens Linn. [Solanaceae] (CFE) or capsaicin (Fluka Biotechnika-CPF) (in addition to the known analgesic properties) has any anti-inflammatory effect comparable to nonsteroidal anti-inflammatory analgesics (NSAIDS). Methods : The effects of ethyl acetate extract of Capsicum frutescens Linn. [Solanaceae] (CFE) and capsaicin (Fluka Biotechnika-CPF) was examined on rat hind paw. Inflammation was induced in the rat’s hind paw by subplantar injections of fresh egg albumin (0.5 ml/kg). Diclofenac (100 mg/kg) was used as the reference anti-inflammatory agent for comparison, while distilled water was used as the placebo. The leucocytes count, corticosterone and C - reactive protein (CRP) levels were measured as biomarkers of inflammation. Data obtained were pooled and analysed using repeated ANOVA, in a general linear model with the CPSS software. Results : Sub-plantar injections of fresh egg albumin (0.5 ml/kg) produced profound and time-related oedema in the rat hind paw of the ‘control’ rats. Diclofenac (DIC, 100 mg/kg, i.p.) and reference capsaicin (CPF, 2.5 mg/kg, i.p.) significantly inhibited paw swelling at (p |
| Databáze: | OpenAIRE |
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