Antidepressive medication and diurnal variation of plasma 17-OHCS levels in depression

Autor: Ranan Rimón, Simo Salonen, Aimo Pekkarinen
Rok vydání: 1968
Předmět:
Zdroj: Journal of Psychosomatic Research. 12:289-295
ISSN: 0022-3999
DOI: 10.1016/0022-3999(68)90083-4
Popis: 1. (1) Diurnal plasma 17-OHCS values were determined for 20 depressed female patients before treatment and after one fortnight and one month of drug therapy. Ten of the patients received monochlorimipramine and the other ten diazepam. 2. (2) There were no significant differences between the mean diurnal plasma 17-OHCS levels of the two patient groups either in the pre-treatment phase or after introducing the drug therapy. 3. (3) The diurnal plasma 17-OHCS values were higher in all depressive patients in the pre-treatment phase than in nonhospitalized healthy medical personnel (p 4. (4) Patients with good remission did not have higher 17-OHCS values than patients with poor remission before drug therapy was initiated. After one month's treatment the values of the good remission group were higher, but only where levels at 9.00 p.m. were compared was the difference statistically significant (p
Databáze: OpenAIRE