An iminophosphine dendrimeric ligand and its evaluation in the Heck reaction

Autor:	Maria Micha-Screttas, Barry R. Steele, Dimitrios P. Catsoulacos, Constantinos G. Screttas, Georgios A. Heropoulos
Rok vydání:	2003
Předmět:	Tertiary amine Ligand Aryl Organic Chemistry Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Acetic acid chemistry Dendrimer Heck reaction Drug Discovery Organic chemistry Phosphine
Zdroj:	Tetrahedron Letters. 44:4575-4578
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(03)00983-3
Popis:	DAB- dendr -(NH 2 ) 32 has been modified to produce two novel dendrimeric P , N -ligands, DAB- dendr -[1,2-(NCHC 6 H 4 PPh 2 )] 32 and DAB- dendr -[1,2-(NHCH 2 C 6 H 4 PPh 2 )] 32 . These were both found to activate electron rich aryl bromides in the Heck reaction. The reactions seem to proceed better in a novel solvent system consisting of an equimolar mixture of a tertiary amine with acetic acid. A marked dependence of the conversion on the [equivalents of dendrimeric ligand]/[Pd] ratio has been observed with conversion decreasing as the ratio of dendrimer equivalents to Pd increases. This phenomenon is attributed to interactions of the arms bearing the metal with neighboring ones within the dendrimer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7aaf56cbc3c8199d25d8f39e93f38652 https://doi.org/10.1016/s0040-4039(03)00983-3 Zobrazit plný text záznamu Full Text from ScienceDirect