Conformation of the piperidine ring in isomeric 1,2,5-trimethyl-4-phenyl(triorganosilyl)piperidin-4-ols from the PMR spectra

Autor:	Alexey V. Varlamov, M. S. Prostakov, V. A. Rezakov, A. A. Fomichev, N. I. Golovtsov
Rok vydání:	1986
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Hydrogen bond Intramolecular force Organic Chemistry Cyclohexane conformation Substituent Piperidine Ring (chemistry) Medicinal chemistry Spectral line Large size
Zdroj:	Chemistry of Heterocyclic Compounds. 22:1208-1213
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00471804
Popis:	A full analysis of the PMR spectra of isomeric promedol alcohols was undertaken for the first time. It was shown that the conformational equilibrium must be taken into account only in the case of the Β isomer, where it is determined mainly by chair-chair interconversion. In the α isomers of 1,2,5-trimethyl-4-triorganosilylpiperidin-4-ols an equilibrium was found between the chair conformation and the two skew boat conformations, which are stabilized by an intramolecular hydrogen bond and by the large size of the triorganosilyl substituent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7aab470115f39616ba4183cc5d85a3c0 https://doi.org/10.1007/bf00471804 Zobrazit plný text záznamu Full text from SpringerLink