Preparation of ibuprofen-loaded HDPE tubular devices for application as urinary catheters
| Autor: | Gean Vitor Salmoria, Edna da Silva Vieira, Luiz Alberto Kanis, Izabelle de Mello Gindri |
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| Rok vydání: | 2017 |
| Předmět: |
Chromatography
Materials science Polymers and Plastics Urinary system 02 engineering and technology General Chemistry Polyethylene Bacterial growth 010402 general chemistry 021001 nanoscience & nanotechnology Ibuprofen 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films chemistry.chemical_compound Crystallinity chemistry Polymer chemistry Materials Chemistry medicine Extrusion High-density polyethylene 0210 nano-technology Melt extrusion medicine.drug |
| Zdroj: | Journal of Applied Polymer Science. 135:45661 |
| ISSN: | 0021-8995 |
| DOI: | 10.1002/app.45661 |
| Popis: | In this study, high-density polyethylene tubes with the incorporation of ibuprofen (IBP) were investigated with a view to their application as urinary catheters. The melt extrusion process was used to prepare the urinary catheters, and the influence of the manufacturing parameters on the material properties was evaluated. Samples prepared at lower temperature resulted in a more homogeneous material with a smoother surface, lower crystallinity, and better mechanical properties. The drug release was faster in the first 4 days, due to the accumulation of the drug on the outer surface of tubes. The concentration of IBP released was similar to the drug content in commercially available topic formulations (5%). Furthermore, after 2 days of immersion, the release achieved the concentration known to inhibit bacterial growth (6 mg/mL). These characteristics indicate that this material has good potential for application in urinary catheters. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45661. |
| Databáze: | OpenAIRE |
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