Chemoenzymatic synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids and their application in the synthesis of an α-hydroxylated β-hexapeptide

Autor: Gijs A. van der Marel, Alessia Amore, Arne van der Gen, Michael van der Hoeven, Reynier A. Tromp, Johannes Brussee, Mark Overhand
Rok vydání: 2001
Předmět:
Zdroj: Tetrahedron: Asymmetry. 12:1109-1112
ISSN: 0957-4166
Popis: A chemoenzymatic and stereoselective synthesis of Fmoc-protected (2 S ,3 S )-2-hydroxy-3-amino acids from 2-furaldehyde is described as well as their application, without prior hydroxyl protection, in the solid-phase synthesis of a novel completely α-hydroxylated β-hexapeptide.
Databáze: OpenAIRE