Autor: |
X M Lu, Camilo Rojas, Barbara S. Slusher, James J. Vornov, Pavel Majer, Krystyna M. Wozniak, Ajit G. Thomas, Takashi Tsukamoto |
Rok vydání: |
2005 |
Předmět: |
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Zdroj: |
Dipeptidyl Aminopeptidases in Health and Disease ISBN: 0306477173 |
Popis: |
We have shown that 2-PMPA, an inhibitor of GCP II, was neuroprotective in in vitro and in vivo models of stroke and effectively attenuated neuropathic pain in a chronic constrictive injury model. These biological effects are likely mediated by GCP II inhibition-induced decreases in extracellular glutamate and/or increases in extracellular NAAG. Therefore, GCP II inhibition may be useful in neurological disorders in which excessive glutamate transmission is pathogenic. In addition, GCP II inhibition may represent a novel glutamate regulating strategy devoid of the side effects that have hampered the development of postsynaptic glutamate receptor antagonists. A lead GCP II inhibitor is currently completing Phase I clinical testing. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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