A synaptocentric view of the neuroendocrine response to stress

Autor:	Jaideep S. Bains, Jaclyn I. Wamsteeker
Rok vydání:	2010
Předmět:	endocrine system medicine.medical_specialty General Neuroscience Glutamate receptor Context (language use) medicine.anatomical_structure Endocrinology nervous system Hypothalamus Parvocellular cell Internal medicine Synaptic plasticity medicine Psychology Nucleus hormones hormone substitutes and hormone antagonists Glucocorticoid Hormone medicine.drug
Zdroj:	European Journal of Neuroscience. 32:2011-2021
ISSN:	0953-816X
Popis:	The essential role of parvocellular neuroendocrine cells (PNCs) in the paraventricular nucleus of the hypothalamus (PVN) is to translate real or perceived challenges into a comprehensive glucocorticoid (GC) hormone response. Synaptic inputs encoding physical and psychological stress engage the hypothalamic-pituitary-adrenal axis (HPA) by increasing PNC activity, and corticotropin-releasing hormone production and release. Following robust recruitment in response to stress, GCs feedback to dampen PNC responses. Here we review the contributions of glutamate and GABA synapses in PVN to the initiation and termination of the stress response. The reliability of HPA responses to a given stress can vary as a function of prior experience. Within this context, we examine possible synaptic correlates that allow this neuroendocrine system to learn and adapt following stress challenges.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a88eb14e07c51972c0a27ab49fd0a41 https://doi.org/10.1111/j.1460-9568.2010.07513.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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