Additional file 3: of Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

Autor:	Tonsing-Carter, Eva, Hernandez, Kyle, Kim, Caroline, Harkless, Ryan, Oh, Alyce, Bowie, Kathleen, West-Szymanski, Diana, Betancourt-Ponce, Mayra, Green, Bradley, Lastra, Ricardo, Gini Fleming, Sarat Chandarlapaty, Conzen, Suzanne
Předmět:	3. Good health
Popis:	Figure S1. SGRM treatment-alone does not affect cell survival in ER+/GR+/PR+ tumor cells. A) Steady-state PR, GR, ER, and β-actin protein expression was evaluated in ER+/GR+ MCF-7 and T-47D cells. B) MCF-7 cells were treated with vehicle (ETOH), 10 nM E2, E2/100 nM Dex, E2/1 μM C134, or E2/1 μM C335 for 2, 4, or 6 h. Steady-state mRNA expression of canonical GR target gene, FKBP5, was significantly repressed following C134 or C335 treatment ($ p
Databáze:	OpenAIRE
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